Why the study?
Is high on-treatment platelet reactivity or residual COX-1 activity associated with recurrence of cardiovascular events in stable cardiovascular outpatients on aspirin monotherapy?
Population
592 stable cardiovascular outpatients treated with aspirin monotherapy for secondary prevention
Comparison
High on-treatment platelet reactivity and high… vs Normal platelet reactivity and normal residual…
Design
Cohort
Follow-up
two years
Authors
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No association seen in stable aspirin outpatients; leaves open whether testing adds value in higher-risk groups.
Is high on-treatment platelet reactivity or residual COX-1 activity associated with recurrence of cardiovascular events in stable cardiovascular outpatients on aspirin monotherapy?
High on-treatment platelet reactivity and residual COX-1 activity do not predict cardiovascular event recurrence in stable patients on aspirin monotherapy, suggesting routine platelet function testing is not clinically useful in this population.
Nagatsuka et al. (2016) studied this question.
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