What question did this study set out to answer?

To evaluate the feasibility and predictive accuracy of the cost-efficient Methylation Screening Array for estimating biological age and blood biomarkers in Japanese individuals.

August 14, 2026Epigenetics ReportsOpen Access

Prediction of biological age and blood biomarkers from DNA methylation profiles measured by the methylation screening array: development and validation of models on Japanese data

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Authors

TSTatsuma ShojiInpex (Japan)YTYui TomoNational Institute of Infectious Diseases RNRyo NakakiInpex (Japan)

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Implication

Cohort study reveals reliable biological age and blood biomarker prediction in Japanese adults using low-cost methylation screening arrays, highlighting scalable epigenetic profiling.

Key Points

To evaluate the feasibility and predictive accuracy of the cost-efficient Methylation Screening Array for estimating biological age and blood biomarkers in Japanese individuals.
Trained Elastic Net linear regression and two-stage residual learning models on DNA methylation profiles and clinical laboratory data from 166 Japanese participants.
Validated the models using an independent cohort of 48 individuals processed at a separate institute.
Evaluated model performance across phenotypic age and 59 clinical biomarkers, including sex-stratified analyses.
Methylation Screening Array profiles accurately predicted phenotypic age in the validation dataset, with improved accuracy when integrating EPIC-based predictions via residual learning.
Multiple clinical biomarkers, especially those associated with leukocyte composition and sex hormone regulation, were reliably predicted from the array data.

Cite This Study

Shoji et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec69fb70b84ec8b912b06 https://doi.org/10.1080/28361512.2026.2715974

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Implication

Cohort study reveals reliable biological age and blood biomarker prediction in Japanese adults using low-cost methylation screening arrays, highlighting scalable epigenetic profiling.

Prediction of biological age and blood biomarkers from DNA methylation profiles measured by the methylation screening array: development and validation of models on Japanese data

Discussion

Member takes

Implication

Key Points

Cite This Study

Prediction of biological age and blood biomarkers from DNA methylation profiles measured by the methylation screening array: development and validation of models on Japanese data

Discussion

Member takes

Implication

Key Points

Cite This Study

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