What question did this study set out to answer?

To evaluate the chemical profile and in vitro anticancer potential of bioactive metabolites from the cyanobacterium Microcystis aeruginosa against gastrointestinal cancer cells.

August 14, 2026Natural Product Research

Antiproliferative potential of Microcystis aeruginosa bioactive compounds against gastrointestinal cancer cells via p53-mediated apoptosis

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Authors

HGHamieh GoshtasbiTabriz University of Medical Sciences PHParichehr HanachiAlzahra University PPParnia PouyaTabriz University of Medical Sciences

Discussion

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Implication

In vitro study demonstrates antiproliferative and apoptotic effects of Microcystis aeruginosa in gastrointestinal cancer cells, indicating potential as natural anticancer agents.

Key Points

To evaluate the chemical profile and in vitro anticancer potential of bioactive metabolites from the cyanobacterium Microcystis aeruginosa against gastrointestinal cancer cells.
Identified Microcystis aeruginosa through morphological and molecular analyses, and profiled bioactive fatty acid esters and pigments using GC–MS and biochemical assays.
Assessed cytotoxicity and apoptotic mechanisms in AGS gastric and SW480 colorectal cancer cell lines using viability assays and Western blot analysis for p53, Bax, and Bcl-2.
Demonstrated dose-dependent cytotoxicity with IC50 values of 365–536 µg/mL in AGS cells and 244–409 µg/mL in SW480 cells at 24 and 48 hours.
Triggered apoptotic signaling in both cell lines via p53 activation, Bax upregulation, and Bcl-2 suppression.

Cite This Study

Goshtasbi et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec6eab70b84ec8b912f8b https://doi.org/10.1080/14786419.2026.2707643

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August 14, 2026Natural Product Research

Antiproliferative potential of Microcystis aeruginosa bioactive compounds against gastrointestinal cancer cells via p53-mediated apoptosis

View Full Paper

Ask AI

Bookmark

Authors

HGHamieh GoshtasbiTabriz University of Medical Sciences PHParichehr HanachiAlzahra University PPParnia PouyaTabriz University of Medical Sciences

Discussion

Member takes

Implication

In vitro study demonstrates antiproliferative and apoptotic effects of Microcystis aeruginosa in gastrointestinal cancer cells, indicating potential as natural anticancer agents.

Key Points

To evaluate the chemical profile and in vitro anticancer potential of bioactive metabolites from the cyanobacterium Microcystis aeruginosa against gastrointestinal cancer cells.
Identified Microcystis aeruginosa through morphological and molecular analyses, and profiled bioactive fatty acid esters and pigments using GC–MS and biochemical assays.
Assessed cytotoxicity and apoptotic mechanisms in AGS gastric and SW480 colorectal cancer cell lines using viability assays and Western blot analysis for p53, Bax, and Bcl-2.
Demonstrated dose-dependent cytotoxicity with IC50 values of 365–536 µg/mL in AGS cells and 244–409 µg/mL in SW480 cells at 24 and 48 hours.
Triggered apoptotic signaling in both cell lines via p53 activation, Bax upregulation, and Bcl-2 suppression.

Cite This Study

Goshtasbi et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec6eab70b84ec8b912f8b https://doi.org/10.1080/14786419.2026.2707643

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