Preclinical study demonstrates Guomin decoction ameliorates atopic dermatitis in mice by balancing macrophage polarization, indicating dual MAPK/NF-κB and JAK-STAT pathway modulation.
This study investigates the therapeutic effects and mechanisms of Guomin decoction (GMJ) on atopic dermatitis (AD). Animal and cellular experiments revealed that GMJ reduces ear swelling and collagen loss in AD-affected mice, modulates inflammatory factors, and inhibits M1 polarization while promoting M2 polarization. Mechanistic studies indicate that GMJ restores the M1/M2 balance in macrophages by dual regulation of the MAPK/NF-κB and JAK-STAT pathways, thereby improving AD.
No takes yet. Share an insight, caveat, or question.
Li et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: