Comparative study evaluates tractography and local field potential contact selection in Parkinson's disease, suggesting improved targeting for stimulation.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for advanced Parkinson’s disease (PD)1. Clinical outcome depends on several factors, including accurate programming of stimulation settings. Conventional programming through monopolar review is a clinically-guided and subjective process. Various techniques can assist to make this process more effective and efficient, including image-based programming using probabilistic tractography2, and neurophysiology-based programming guided by local field potential (LFP) recordings3.
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Wiggerts et al. (2026) studied this question.
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