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August 14, 2026AnimalsOpen Access

Artemisia argyi Polysaccharides Protect Intestinal Health by Enhancing Antioxidant Capacity in Suckling Lambs Under Cold Exposure

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Authors

SZShuang ZhengInner Mongolia Agricultural UniversityXJXiao JinInner Mongolia Agricultural UniversityJSJian SongShandong Provincial Hospital

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Implication

Randomized trial demonstrates that Artemisia argyi polysaccharides improve intestinal antioxidant defense and growth in cold-stressed lambs, highlighting a protective nutritional strategy.

Key Points

  • To evaluate the protective effects of Artemisia argyi polysaccharides on intestinal barrier function, antioxidant capacity, and growth performance in suckling lambs exposed to cold stress.
  • Randomly assigned 24 7-day-old suckling lambs to receive milk replacer supplemented with 0 (Control), 0.5 (Low), 1.0 (Medium), or 2.0 g/kg (High) of Artemisia argyi polysaccharides (AAPs) for 14 days under cold conditions (−8 °C to −5 °C).
  • Evaluated growth performance, nutrient digestibility, digestive enzyme activity, antioxidant status, intestinal morphology, tight junction gene expression, and cecal microbiota composition.
  • Supplementation with 1.0 g/kg AAPs significantly increased average daily gain, reduced feed-to-gain ratio, and improved the digestibility of crude protein, ether extract, calcium, and phosphorus (p < 0.05).
  • The 1.0 g/kg dose activated the jejunal Nrf2/Keap1 pathway, elevated antioxidant enzymes (SOD1, CAT, GSH-Px), decreased colonic malondialdehyde, and improved intestinal barrier integrity by upregulating Claudin-1, Claudin-4, and ZO-1 while reducing serum D-lactate and diamine oxidase (p < 0.05).
  • AAP supplementation altered cecal microbial structure by enriching the relative abundance of Anaerofilum and decreasing Akkermansia.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec735b70b84ec8b913639https://doi.org/10.3390/ani16162512
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