What question did this study set out to answer?

To elucidate the bottom-up self-assembly mechanisms and multivariable control of inorganic hydroxyapatite nanorods into ordered liquid crystal phases mimicking bone extracellular matrix.

August 14, 2026ACS Sustainable Chemistry & Engineering

Multivariable Modulation of the Self-Assembly Behavior and Chiral Nematic Phase of Hydroxyapatite Nanorods

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Authors

WZWei ZhouUniversity of Jinan WZWendong ZhangUniversity of Jinan RZRuixi ZhangJinan University

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Implication

Experimental study demonstrates multivariable control over hydroxyapatite nanorod liquid crystal phase transitions, suggesting new avenues for designing biomimetic bone extracellular matrix materials.

Key Points

To elucidate the bottom-up self-assembly mechanisms and multivariable control of inorganic hydroxyapatite nanorods into ordered liquid crystal phases mimicking bone extracellular matrix.
Synthesized hydroxyapatite nanorods with tunable aspect ratios and surface charges using a citrate-mediated hydrothermal method.
Assessed self-assembly behavior and liquid crystal phase transitions across varying nanorod concentrations, aspect ratios, pH levels, and ionic strengths.
Hydroxyapatite nanorods exhibited a concentration-dependent phase transition from isotropic to nematic to chiral nematic liquid crystalline states.
Higher aspect ratios enhanced entropic forces and reduced pitch, with chiral superstructure formation driven by hydrogen bonding and Ca2+–COO– coordination.
Liquid crystal stability was dynamically modulated by ionic strength and pH through surface protonation and electrical double-layer effects.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec754b70b84ec8b91399f https://doi.org/10.1021/acssuschemeng.6c07574

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Multivariable Modulation of the Self-Assembly Behavior and Chiral Nematic Phase of Hydroxyapatite Nanorods

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Key Points

Cite This Study

Multivariable Modulation of the Self-Assembly Behavior and Chiral Nematic Phase of Hydroxyapatite Nanorods

Discussion

Member takes

Implication

Key Points

Cite This Study

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