Review demonstrates the potent anti-inflammatory effects and metabolic risks of synthetic glucocorticoids, highlighting trade-offs in long-term immunosuppressive therapy.
The adrenal cortex produces powerful steroid hormones called glucocorticoids. They are crucial for controlling immunological response, metabolism, and stress response. Because of their potent anti-inflammatory and immunosuppressive properties, synthetic counterparts (such as prednisone and dexamethasone) are frequently recommended; nevertheless, prolonged use may result in metabolic adverse effects.
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E. et al. (2026) studied this question.
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