What question did this study set out to answer?

To determine how systemic glucocorticoid administration in humans modulates the specific functions of B cells, helper T cells, and suppressor T cells in antibody synthesis.

April 1, 1978Journal of Clinical InvestigationOpen Access

Glucocorticoids Administered In Vivo Inhibit Human Suppressor T Lymphocyte Function and Diminish B Lymphocyte Responsiveness in In Vitro Immunoglobulin Synthesis

View Full Paper

Ask AI

Bookmark

To determine how systemic glucocorticoid administration in humans modulates the specific functions of B cells, helper T cells, and suppressor T cells in antibody synthesis.
Obtained peripheral blood lymphocytes from healthy volunteers prior to and 4 hours after intravenous methylprednisolone administration.
Cultured unfractionated lymphocytes and isolated B and T cell subsets in vitro using pokeweed mitogen stimulation to evaluate immunoglobulin production.
Unfractionated peripheral blood lymphocytes demonstrated a consistent mean decrease of approximately 50% in immunoglobulin and total protein synthesis following steroid administration.
Post-treatment B cells displayed a marked reduction in immunoglobulin production to 20% of normal across IgG, IgM, and IgA classes.
Post-treatment T cells retained normal helper activity but completely lacked suppressor T lymphocyte activity at high T-to-B cell ratios.

Authors

ASAndrew SaxonUniversity of California, Los Angeles RSRonald H. StevensVrije Universiteit Amsterdam SRS J RamerUniversity of California, Los Angeles

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Experimental trial reveals intravenous methylprednisolone reduces B cell function and abolishes suppressor T cells in healthy volunteers, indicating differential lymphocyte regulation.

Cite This Study

Saxon et al. (1978) studied this question.

synapsesocial.com/papers/6a941b162ef26ce196215c2f https://doi.org/10.1172/jci109017

View Full Paper

Ask AI

Bookmark

Implication

Experimental trial reveals intravenous methylprednisolone reduces B cell function and abolishes suppressor T cells in healthy volunteers, indicating differential lymphocyte regulation.

Glucocorticoids Administered In Vivo Inhibit Human Suppressor T Lymphocyte Function and Diminish B Lymphocyte Responsiveness in In Vitro Immunoglobulin Synthesis

Key Points

Discussion

Implication

Cite This Study

Glucocorticoids Administered In Vivo Inhibit Human Suppressor T Lymphocyte Function and Diminish B Lymphocyte Responsiveness in In Vitro Immunoglobulin Synthesis

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider