Case report demonstrates use of topical sirolimus for a giant angiokeratoma circumscriptum naeviforme, highlighting mTOR inhibition as a viable therapy for rare vascular anomalies.
We report an 18-year-old male with a 20 cm angiokeratoma circumscriptum naeviforme, the largest case on record among fewer than 50 reported worldwide. As standard treatments proved insufficient, topical sirolimus was initiated, highlighting mTOR inhibition as a potential therapeutic avenue for this exceptionally rare vascular anomaly.
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Grempel et al. (2026) studied this question.
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