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August 14, 2026BMC GeriatricsOpen Access

Non-pharmacological interventions for older adults with mild cognitive impairment: an umbrella review

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Authors

DTDiana Carolina Tiga-LozaEVEdwing Alberto Urrea VegaRCRaquel Rivera Carvajal

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Overview

Umbrella review demonstrates cognitive benefits of multicomponent non-pharmacological therapies in older adults with mild cognitive impairment, suggesting memory and executive function gains.

Key Points

  • Synthesize evidence from systematic reviews and meta-analyses evaluating multicomponent non-pharmacological interventions designed to improve cognitive function in community-dwelling older adults with mild cognitive impairment.
  • Conducted an umbrella review following PRISMA, PRIOR, and JBI guidelines across Web of Science, Embase, PubMed, BIREME, Cochrane Library, and Google Scholar for systematic reviews published from 2012 to 2025.
  • Evaluated review methodological quality via AMSTAR 2 and certainty of evidence using GRADE, performing a narrative synthesis across identified randomized controlled trials.
  • Identified 16 reviews (5 systematic reviews, 11 meta-analyses) covering 84 unique primary randomized controlled trials and 5,818 participants (median age 74.8 years [IQR 71.7–77.6], session duration 60 min, 2 sessions/week for 16 weeks).
  • Combined cognitive-physical interventions were most common, with statistically significant improvements reported most frequently in memory (57.1%), executive function (54.1%), global cognition (47.1%), and attention (42.9%) across trials.

Cite This Study

Tiga-Loza et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec775b70b84ec8b913d2ehttps://doi.org/10.1186/s12877-026-07933-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonpharmacological Multimodal Interventions for Cognitive Functions in Older Adults With Mild Cognitive Impairment: Scoping Review (Preprint)2024
  2. 2Evaluating the Effectiveness of Cognitive Interventions for Healthy and Mild Cognitive Impairment Adults: A Comprehensive Umbrella Meta‐Analysis2025 · 3 citations
  3. 3Comparative Effectiveness of Interventions for Global Cognition in Patients With Mild Cognitive Impairment: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials2021 · 32 citations
  4. 4EFFECTIVE MULTICOMPONENT-INTERVENTIONS ON PHYSICAL CAPACITY, COGNITIVE FUNCTION AND INSTRUMENTAL-ACTIVITIES-OF-DAILY-LIVING ARE NOT THE SAME FOR ELDERLY PEOPLE WITH NORMAL AND MILD-IMPAIRED-COGNITION2026
  5. 5Comparative efficacy of seven nonpharmacological interventions on global cognition in older adults with and without mild cognitive impairment: a network meta-analysis of randomized controlled trials2024 · 20 citations