Key result
ICIs and CAR T-cell therapies are linked to increased CV adverse events, including myocarditis.
Why the study?
Immunotherapies are accompanied by increasingly recognized adverse events that pose new challenges for patient care and expand the scope of cardio-oncology.
This review provides a comprehensive overview of the mechanisms, diagnosis, and management of cardiotoxicities associated with immune checkpoint inhibitors and CAR T-cell therapies, emphasizing early recognition and aggressive immunosuppressive treatment for ICI-myocarditis.
Warrants clinician awareness during therapy; leaves open prospective data on incidence and optimal management.
Over the last decade, immunotherapy has transformed oncology, with an ever-expanding list of indications. As with any therapeutic class, these agents are accompanied by adverse events that are increasingly recognized and pose new challenges for patient care expanding the scope of cardio-oncology. Using the PubMed database, this narrative review summarizes the cardiovascular adverse events associated with the most commonly used immunotherapies, immune checkpoint inhibitors (ICIs), with a focus on the mechanisms, epidemiology, diagnosis, treatment, and monitoring of ICI-associated myocarditis. We also review accelerated atherosclerotic disease, heart failure, cardiomyopathy (including stress-induced cardiomyopathy), arrhythmias, and pericardial disease related to ICI therapy. Finally, we outline CAR T-cell therapy associated cardiotoxicity, including cytokine release syndrome.
No takes yet. Share an insight, caveat, or question.
Naser et al. (2026) conducted a review in Cancer and cardiovascular adverse events. Immune checkpoint inhibitors and CAR T-cell therapy was evaluated. Immune checkpoint inhibitors and CAR T-cell therapies are associated with cardiovascular adverse events, including myocarditis, accelerated atherosclerosis, heart failure, arrhythmias, and pericardial disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: