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August 14, 2026BMC Endocrine DisordersOpen Access

Risk of type 2 diabetes mellitus associated with lipid-related metabolic indicators: a diabetes family cohort study in China

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Authors

HLHaowei LiShenyang Ligong UniversityYHYilu HuangTaizhou UniversityDYDonghui YangFudan University

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Overview

A cohort study demonstrates that composite lipid indices predict incident type 2 diabetes in high-risk families, highlighting their utility for early metabolic risk screening.

Key Points

  • To evaluate the associations between lipid-related metabolic indicators and the risk of developing incident type 2 diabetes mellitus in a family-based cohort.
  • Prospective diabetes family cohort study tracking 1,257 participants without baseline diabetes in Taizhou, China, over an average follow-up of 3.92 years.
  • Evaluated conventional lipid indicators (TG, TC, HDL-C, LDL-C), triglyceride-glucose-derived indices, CVAI, and HOMA-IR using mixed-effects and within-family Cox proportional hazards models.
  • Incident type 2 diabetes occurred in 68 of 1,257 participants over the 3.92-year follow-up period.
  • Significant risk increases occurred with higher TyG (HR = 1.758, 95% CI: 1.182–2.616), TyG-WHtR (HR = 2.108, 95% CI: 1.468–3.027), HOMA-IR (HR = 1.195, 95% CI: 1.038–1.376), and CVAI (HR = 1.013, 95% CI: 1.006–1.020), whereas traditional lipid markers showed no significant association.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec79cb70b84ec8b9140a7https://doi.org/10.1186/s12902-026-02484-8
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