Review reveals the mechanisms of PLPPR3 in neuronal filopodia formation, highlighting its key role in coordinating membrane protrusion and neuronal morphogenesis.
Phospholipid phosphatase-related protein 3 (PLPPR3) is a regulator of neuronal membrane dynamics and cytoskeletal remodeling. In this review, we synthesize current evidence positioning PLPPR3 as a key driver of neuronal filopodia formation, highlighting its roles in lipid signaling, membrane protrusion and actin organization. By consolidating recent molecular, cellular, and functional studies, we propose a mechanistic framework for PLPPR3-dependent filopodia formation and outline its implications for neuronal morphogenesis.
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Böddeker et al. (2026) studied this question.
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