Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 1992Journal of the American Chemical Society

Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity

View Full Paper
Ask AI
Bookmark
Share

Authors

PKPaul A. KeiferAgilent Technologies (United States)TSTim Saarinen

Discussion

Loading...

Member takes

Implication

Methodological study demonstrates enhanced sensitivity in gradient heteronuclear correlation spectroscopy, indicating higher spectral quality for biomolecular analysis.

Key Points

  • Develop a pulsed field gradient heteronuclear single quantum correlation experiment that yields pure absorption line shapes while overcoming gradient-induced sensitivity losses.
  • Incorporated pulsed magnetic field gradients into the heteronuclear single quantum correlation (HSQC) pulse scheme for coherence selection and artifact suppression.
  • Implemented a sensitivity-enhancement scheme designed to preserve and refocus both orthogonal coherence transfer pathways.
  • Recovered the theoretical square-root-of-two sensitivity loss typically incurred during gradient coherence selection.
  • Produced two-dimensional heteronuclear correlation spectra with pure absorption line shapes and clean background solvent suppression.

Cite This Study

Keifer et al. (1992) studied this question.

synapsesocial.com/papers/6a7ec891ec6d7e203fcda737https://doi.org/10.1021/ja00052a088
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective excitation in high-resolution NMR1991 · 148 citations
  2. 2Electronic Interactions and Interchromophore Excitation Transfer1994 · 258 citations
  3. 3Tribute to Roland Lindh2024
  4. 4Spotlights on Recent <i>JACS</i> Publications, Volume 146, Issue 242024 · 1 citations
  5. 5Quantum-Chemical Descriptors in QSAR/QSPR Studies1996 · 1,642 citations