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March 25, 2022Liver TransplantationOpen Access

Cirrhotic cardiomyopathy: Appraisal of the original and revised criteria in predicting posttransplant cardiac outcomes

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Why the study?

Cirrhotic cardiomyopathy is a risk factor for cardiovascular disease after liver transplantation, prompting assessment of whether the original 2005 or revised 2020 criteria better predict posttransplant major adverse cardiac events.

Does the revised 2020 criteria for cirrhotic cardiomyopathy predict major adverse cardiac events after liver transplantation better than the original 2005 criteria?

Population

210 adult LT recipients

Comparison

Original 2005 vs revised 2020 CCM criteria

Design

Single-center retrospective study

Authors

ASAshley SpannVanderbilt University Medical CenterCCChristopher L. CoeUniversity of Wisconsin–MadisonTATeminioluwa AjayiNational Institutes of Health

Discussion

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Member takes

Overview

Should not yet change pre-LT CCM screening; supports 2020 over 2005 criteria but leaves open prospective validation.

Structured PICO

Does the revised 2020 criteria for cirrhotic cardiomyopathy predict major adverse cardiac events after liver transplantation better than the original 2005 criteria?

P
Population
210 adult liver transplantation (LT) recipients. Excluded: insufficient pre-LT echocardiographic data, prior ischemic heart disease, portopulmonary hypertension, or longitudinal care elsewhere.
I
Intervention
Diagnosis of cirrhotic cardiomyopathy (CCM) using the revised 2020 criteria
C
Comparator
Diagnosis of cirrhotic cardiomyopathy (CCM) using the original 2005 criteria
O
Outcome
Composite of major adverse cardiac events (MACE) after transplant (arrhythmia, heart failure, cardiac arrest, and/or cardiac death)composite

The revised 2020 criteria for cirrhotic cardiomyopathy, specifically abnormal septal e', successfully predict major adverse cardiac events after liver transplantation, validating the updated definition.

Cite This Study

Spann et al. (2022) studied this question.

synapsesocial.com/papers/6a7ec95d5b5966d82bc30160https://doi.org/10.1002/lt.26460
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cirrhotic Cardiomyopathy After Transplantation: Neither the Transient Nor Innocent Bystander2018 · 64 citations
  2. 2The prevalence of cirrhotic cardiomyopathy according to different diagnostic criteria2020 · 70 citations
  3. 3Prevalence and outcome of diastolic dysfunction in liver transplantation recipients2014 · 47 citations
  4. 4Clinical predictors of post–liver transplant new-onset heart failure2013 · 69 citations
  5. 5Systolic heart failure after liver transplantation: Incidence, predictors, and outcome2018 · 36 citations