Why the study?
In pulmonary arterial hypertension, the mechanisms causing the right ventricle to transition from adaptive hypertrophy to maladaptive decompensation and right heart failure remain unknown.
Population
Rodent model of pulmonary arterial hypertension
Comparison
Adaptive hypertrophy phase vs decompensated maladaptive right heart failure phase
Design
Animal experimental study
We only have this paper's title and publication details.
Read it at the sourceShould not change PAH practice; leaves open whether mTORC1-driven autophagy inhibition mediates the adaptive-to-maladaptive RV transition.
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A 2023 study studied this question.
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