Diagnostic Value of Pericardial Biopsy
Why the study?
Does pericardioscopy-guided extensive sampling improve the diagnostic value and efficiency of pericardial biopsy compared to fluoroscopy-guided standard sampling in patients with large pericardial effusion?
Population
49 patients with a large pericardial effusion undergoing parietal pericardial biopsy.
Comparison
Pericardioscopy guidance with standard sampling… vs Fluoroscopic control and standard sampling.
Design
Cohort
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for pericardioscopy-guided pericardial biopsy; prospective trials needed before clinical adoption.
Structured PICO
Does pericardioscopy-guided extensive sampling improve the diagnostic value and efficiency of pericardial biopsy compared to fluoroscopy-guided standard sampling in patients with large pericardial effusion?
P
Population
49 patients with a large pericardial effusion undergoing parietal pericardial biopsy.
I
Intervention
Pericardioscopy guidance with standard sampling (4 to 6 samples, Group 2) or extensive sampling (18 to 20 samples, Group 3).
C
Comparator
Fluoroscopic control and standard sampling (3 to 6 samples, Group 1).
O
Outcome
Diagnostic value (defined as a new diagnosis uncovered, etiology revealed, clinical diagnosis confirmed, and the biopsy false-negative) and sampling efficiency.surrogate
Pericardioscopy-guided extensive sampling significantly improves the diagnostic yield and reduces false-negative rates of pericardial biopsy compared to standard fluoroscopic guidance.
Cite This Study
Seferović et al. (2003) studied this question.