Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants versus Vitamin K Antagonist Oral Anticoagulants in Patients Undergoing Radiofrequency Catheter Ablation of Atrial Fibrillation: A Meta-Analysis
Why the study?
Do NOACs reduce thromboembolic and bleeding complications compared to VKAs in patients undergoing radiofrequency catheter ablation of atrial fibrillation?
Population
9,881 patients across 25 studies undergoing radiofrequency catheter ablation (RFCA) of atrial fibrillation.
Comparison
Non-vitamin K antagonist oral anticoagulants… vs Vitamin K antagonist oral anticoagulants during…
Design
Meta-analysis
Authors
Discussion
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Implication
NOACs may be preferred over VKAs to reduce bleeding in AF ablation; confirms comparable thromboembolic safety in pooled data.
Structured PICO
Do NOACs reduce thromboembolic and bleeding complications compared to VKAs in patients undergoing radiofrequency catheter ablation of atrial fibrillation?
P
Population
9,881 patients across 25 studies undergoing radiofrequency catheter ablation (RFCA) of atrial fibrillation.
I
Intervention
Non-vitamin K antagonist oral anticoagulants (NOACs) during the periprocedural phase of RFCA.
C
Comparator
Vitamin K antagonist oral anticoagulants (VKAs) during the periprocedural phase of RFCA.
O
Outcome
Thromboembolic complications and bleeding complications.safety
NOACs are safe and associated with fewer bleeding complications compared to VKAs in patients undergoing radiofrequency catheter ablation for atrial fibrillation.
Limitations
- no patients-level data were available
Cite This Study
Santarpia et al. (2015) studied this question.