Population
Vero cells infected with Enterovirus 71 (EV71) strains (EV71-HP and EV71-CCA)
Comparison
Substitutional mutations of the highly conserved… vs Parental EV71 strains (EV71-HP and EV71-CCA)
Design
Preclinical
Authors
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Identifies a critical viral maturation target that should not yet change clinical practice; leaves open the potential for.
The highly conserved VP1A107 residue is essential for EV71 maturation, regulating VP0 cleavage and subsequent viral uncoating.
Zhang et al. (2017) studied this question.
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