Why the study?
Does transfection with hepatic lipase cDNA increase the uptake of apoB-containing lipoproteins in hepatoma cells grown as solid tumors in vivo?
Population
Hepatoma cells (HTC 7288c) grown as solid tumors in vivo in rats
Comparison
Transfection with a cDNA encoding hepatic lipase vs Untransfected hepatoma cells grown in the same rat
Design
Preclinical
Authors
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Supports hepatic lipase in apoB-lipoprotein removal in vivo; extends in vitro data but leaves human relevance open.
Does transfection with hepatic lipase cDNA increase the uptake of apoB-containing lipoproteins in hepatoma cells grown as solid tumors in vivo?
Hepatic lipase facilitates the removal of apoB-containing lipoproteins in vivo, though other factors also play a major role in hepatic lipoprotein removal.
Donner et al. (1998) studied this question.
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