Experimental study demonstrates the rapid mechanochemical synthesis of a novel hybrid amide within one minute, highlighting an efficient solvent-free method for chemical synthesis.
Herein, we report the rapid mechanochemical synthesis of a novel hybrid amide, (±)-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylacetamide. The target compound was obtained via direct acylation of 1,4-benzodioxan-6-amine with (±)-2-chloro-2-phenylacetyl chloride under ball-milling conditions in only 1 min. Its structure was confirmed by 1H and 13C NMR, IR spectroscopy, and HRMS.
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Dimitrova et al. (2026) studied this question.
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