Key result
Right-sided infective endocarditis not associated with cardiac devices or intravenous drug use (NODID RSIE) was independently associated with a significantly higher risk of in-hospital endocarditis-related events compared to other RSIE forms (OR 19.29).
Why the study?
Predisposing factors and prognosis for right-sided infective endocarditis not associated with cardiac devices or intravenous drug use remain unclear.
Does NODID RSIE have a worse prognosis compared to non-NODID RSIE in patients with right-sided infective endocarditis?
Population
300 patients with IE in a single reference center cohort and 320 RSIE cases across 4 meta-analysis studies
Comparison
NODID RSIE vs non-NODID RSIE forms
Design
Retrospective cohort study and meta-analysis
Authors
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Clinicians should not view all RSIE as low-risk; challenges consensus of favorable RSIE prognosis and leaves open NODID-specific strategies.
Cohort (n=57)
No
Does NODID RSIE have a worse prognosis compared to non-NODID RSIE in patients with right-sided infective endocarditis?
Odds Ratio: 19.29 (95% CI 2.23–167.16)
Absolute Event Rate: 41% vs 6%
p-value: p=0.007
NODID RSIE is associated with significantly higher in-hospital mortality and need for open-heart surgery compared to other forms of RSIE, challenging the notion that RSIE generally has a good prognosis.
Vilardell et al. (2020) conducted a cohort in Right-Sided Infective Endocarditis (n=57). Right-sided infective endocarditis not associated with cardiac devices or intravenous drug use (NODID RSIE) vs. Right-sided infective endocarditis associated with cardiac devices or intravenous drug use (non-NODID RSIE) was evaluated on In-hospital endocarditis-related events (mortality or open-heart surgery) (OR 19.29, 95% CI 2.23-167.16, p=0.007). Right-sided infective endocarditis not associated with cardiac devices or intravenous drug use (NODID RSIE) was independently associated with a significantly higher risk of in-hospital endocarditis-related events compared to other RSIE forms (OR 19.29).
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