What question did this study set out to answer?

To evaluate the relationship between medication adherence, serum uric acid levels, and diet with recurrent attacks in patients with gouty arthritis.

September 2, 2021The Egyptian RheumatologistOpen Access

Relationship of medication adherence, serum uric acid level and diet to recurrent attacks of gout

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Authors

EDEsha DasguptaUniversity of Birmingham ZCZhan P. ChongInternational Medical University MTMing N. Ting

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Implication

Observational study reveals recurrent flares associate with purine intake and uric acid rather than adherence in gout patients, suggesting current therapy doses remain insufficient.

Key Points

To evaluate the relationship between medication adherence, serum uric acid levels, and diet with recurrent attacks in patients with gouty arthritis.
Follow-up study of 89 patients with gouty arthritis (84 males, 5 females; mean age 55.4 ± 13.7 years; disease duration 12.22 ± 9.2 years; body mass index 24.67 ± 5.01).
Collected socio-demographic data, gout attack frequency over 6 months, acute intake of purine-rich foods, and adherence to urate-lowering therapies (ULT) via a structured questionnaire.
While 75.6% (65/86) of patients taking urate-lowering therapy were adherent, high adherence was not associated with lower serum uric acid levels or reduced risk of recurrent gout attacks.
Recurrent gout attacks were significantly associated with high serum uric acid levels [OR = 2.86 (95% CI: 1.52–5.39)], acute purine-rich food intake [OR = 2.01 (95% CI: 1.09–3.73)], and obesity [OR = 1.58 (95% CI: 1.09–2.32)].

Cite This Study

Dasgupta et al. (2021) studied this question.

synapsesocial.com/papers/6a7eefbae9bb045a73c30148 https://doi.org/10.1016/j.ejr.2021.08.010

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Implication

Observational study reveals recurrent flares associate with purine intake and uric acid rather than adherence in gout patients, suggesting current therapy doses remain insufficient.

Relationship of medication adherence, serum uric acid level and diet to recurrent attacks of gout

Discussion

Member takes

Implication

Key Points

Cite This Study

Relationship of medication adherence, serum uric acid level and diet to recurrent attacks of gout

Discussion

Member takes

Implication

Key Points

Cite This Study

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