February 20, 2003Circulation Research

High-Density Lipoproteins Protect Isolated Rat Hearts From Ischemia-Reperfusion Injury by Reducing Cardiac Tumor Necrosis Factor-α Content and Enhancing Prostaglandin Release

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Why the study?

Does the administration of high-density lipoproteins (HDLs) improve postischemic functional recovery and reduce ischemia-reperfusion injury in isolated rat hearts?

Population

Buffer-perfused isolated rat hearts undergoing a 20-minute low-flow ischemia followed by a 30-minute…

Comparison

High-density lipoproteins at physiological… vs Control

Design

Preclinical

Follow-up

30 minutes (reperfusion phase)

Authors

LCLaura CalabresiGeneral / Preventive / Lipids GRGiuseppe RossoniUniversity of Milan MGMonica GomaraschiUniversity of Milan

Discussion

Member takes

Implication

Hypothesis-generating for HDL cardioprotection in rat ischemia-reperfusion; leaves open translation to human myocardial injury.

Structured PICO

Does the administration of high-density lipoproteins (HDLs) improve postischemic functional recovery and reduce ischemia-reperfusion injury in isolated rat hearts?

Population

Buffer-perfused isolated rat hearts undergoing a 20-minute low-flow ischemia followed by a 30-minute reperfusion

Intervention

High-density lipoproteins (HDLs) at physiological concentrations (0.5 and 1.0 mg/mL) administered during the 10 minutes immediately before ischemia

Comparator

Control (no HDL, lipid-free apoA-I, or phosphatidylcholine liposomes)

Outcome

Postischemic functional recovery and creatine kinase release in the coronary effluentsurrogate

HDLs exert direct cardioprotection against ischemia-reperfusion injury in isolated rat hearts by removing TNF-alpha from the ischemic myocardium and enhancing prostaglandin release.

Cite This Study

Calabresi et al. (2003) studied this question.

synapsesocial.com/papers/6a7ef12c084666b5350d32f7 https://doi.org/10.1161/01.res.0000054201.60308.1a

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High-Density Lipoproteins Protect Isolated Rat Hearts From Ischemia-Reperfusion Injury by Reducing Cardiac Tumor Necrosis Factor-α Content and Enhancing Prostaglandin Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High-Density Lipoproteins Protect Isolated Rat Hearts From Ischemia-Reperfusion Injury by Reducing Cardiac Tumor Necrosis Factor-α Content and Enhancing Prostaglandin Release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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