Key result
The combination of Exo/miR-19a/19b and MSC transplantation significantly enhanced the recovery of cardiac function and reduced cardiac fibrosis in a preclinical mouse model of myocardial infarction.
Why the study?
The study aimed to investigate whether exogenous miR-19a/19b combined with bone marrow-derived mesenchymal stem cell transplantation protects cardiac function and inhibits fibrosis in myocardial infarction.
Does the combination of miR-19a/19b-loaded exosomes and MSC transplantation improve cardiac function and reduce fibrosis in a preclinical model of myocardial infarction?
Does the combination of miR-19a/19b-loaded exosomes and MSC transplantation improve cardiac function and reduce fibrosis in a preclinical model of myocardial infarction?
The combination of miR-19a/19b-loaded exosomes and MSC transplantation provides a potential regenerative strategy to attenuate myocardial infarction damage in preclinical models.
Do not change practice; leaves open whether this combination will improve human post-MI function.
Aim: We aimed to investigate the protection of exogenous miR-19a/19b with bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation on cardiac function and inhibition of fibrosis in myocardial infarction (MI). Materials & methods: BM-MSC-derived exosomes were used to deliver miR-19a/19b (exo/miR-19a/19b) to the cultured cardiac HL-1 cells, and the apoptosis of cells were evaluated. Exo/miR-19a/19b and BM-MSCs were also transplanted to an in vivo MI mouse model. The recovery of cardiac function was assessed and the level of cardiac fibrosis was determined. Results: Exo/miR-19a/19b and MSCs reduced the area of cardiac fibrosis in the heart tissue in the mouse MI model. Using BM-MSC-derived exosomes as a vehicle, miR-19a/19b significantly suppressed the apoptosis of cardiac HL-1 cells. The combination of Exo/miR-19a/19b and MSC transplantation significantly enhanced the recovery of cardiac function and reduced cardiac fibrosis in the MI model. Conclusion: Our study provides an effective regenerative intervention strategy to attenuate the damage of MI.
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Wang et al. (2020) studied Myocardial infarction. Exo/miR-19a/19b and BM-MSC transplantation was evaluated on Recovery of cardiac function and level of cardiac fibrosis. The combination of Exo/miR-19a/19b and MSC transplantation significantly enhanced the recovery of cardiac function and reduced cardiac fibrosis in a preclinical mouse model of myocardial infarction.
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