Key result
Routine manual thrombus aspiration during primary percutaneous coronary intervention did not significantly reduce all-cause mortality compared to PCI alone in patients with STEMI (HR 0.789).
Why the study?
The study evaluated the effect of a thrombus aspiration strategy on outcomes and its interaction with D-dimer levels in patients with STEMI undergoing primary PCI in real-world settings.
Does manual thrombus aspiration reduce all-cause mortality in patients with STEMI undergoing primary PCI?
Population
1,295 patients with STEMI undergoing primary PCI
Comparison
TA+PCI vs PCI-only
Design
Cohort study
Follow-up
Mean follow-up of 2.5 years
Authors
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Should not change nonroutine TA practice in STEMI; leaves open D-dimer selection as hypothesis-generating pending trials.
Cohort (n=1,295)
No
Does manual thrombus aspiration reduce all-cause mortality in patients with STEMI undergoing primary PCI?
Hazard Ratio: 0.789 (95% CI 0.556–1.12)
Absolute Event Rate: 8.5% vs 16.2%
p-value: p=0.185
While routine manual thrombus aspiration during primary PCI for STEMI does not improve overall clinical outcomes, it may significantly reduce all-cause mortality in patients with high baseline D-dimer levels.
Li et al. (2021) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=1,295). Thrombus aspiration vs. PCI only was evaluated on All-cause mortality (HR 0.789, 95% CI 0.556-1.120, p=0.185). Routine manual thrombus aspiration during primary percutaneous coronary intervention did not significantly reduce all-cause mortality compared to PCI alone in patients with STEMI (HR 0.789).
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