Key result
Selective Kv1.5 channel blockers with a biaromatic structure demonstrate the ability to prevent the development of atrial arrhythmias without affecting ventricular refractoriness in preclinical models.
Why the study?
Selective Kv1.5 blockade is a promising approach to control atrial arrhythmias without the adverse ventricular effects associated with classical hERG-subtype potassium channel blockers.
Do Kv1.5-channel blockers with a biaromatic structure prolong atrial effective refractory period without affecting ventricular refractoriness in preclinical models?
Do Kv1.5-channel blockers with a biaromatic structure prolong atrial effective refractory period without affecting ventricular refractoriness in preclinical models?
Selective Kv1.5 channel blockers with a biaromatic structure represent a promising class of atrial-selective antiarrhythmic agents that avoid adverse ventricular effects.
No practice change for AF yet; leaves open clinical translation of these atrial-selective biaromatic Kv1.5 blockers.
The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, I Kur , that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ventricular effects associated with classical hERG-subtype potassium channel blockers (Kv11.1). This review considers all currently known Kv1.5-channel blockers with a biaromatic structure and data on their biological properties. For many of the Kv1.5-selective compounds studied, the ability to prevent the development of atrial arrhythmias without affecting ventricular refractoriness was confirmed.
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Г. В. Мокров (2023) conducted a review in Atrial arrhythmias. Kv1.5 channel blockers with biaromatic structure was evaluated. Selective Kv1.5 channel blockers with a biaromatic structure demonstrate the ability to prevent the development of atrial arrhythmias without affecting ventricular refractoriness in preclinical models.
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