Population
61 subjects (with a subset of 12 for resting state functional connectivity)
Comparison
Application of two different heat pain levels vs Comparison between HIGH and LOW pain levels
Design
Cross-sectional
Authors
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Indicates non-linear BOLD responses to pain; leaves open distinct functional roles of activations versus deactivations.
Brain signal activations and deactivations during pain lack a linear relationship, suggesting they underlie different aspects of the pain experience.
Kong et al. (2009) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: