Why the study?
Does cardiac-specific overexpression of A20 improve cardiac function and reduce remodeling after myocardial infarction in a murine model?
Population
Transgenic mice containing the human A20 gene under the control of the alpha-myosin heavy chain promoter and…
Comparison
Constitutive cardiac-specific overexpression of… vs Control animals without A20 overexpression
Design
Preclinical
Follow-up
7 days
Authors
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Supports further exploration of A20 as a therapeutic target post-MI; leaves open translation from murine models to clinical practice.
Does cardiac-specific overexpression of A20 improve cardiac function and reduce remodeling after myocardial infarction in a murine model?
Cardiac-specific overexpression of A20 protects the murine heart against remodeling, apoptosis, and inflammation following acute myocardial infarction.
Li et al. (2007) studied this question.
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