Key result
High-cholesterol, high-fat diet induces atherosclerosis in ~99% of baboons and increases arterial stiffness.
Answers are grounded in this paper and cite their sources.
BACKGROUND: The purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model. METHODS: We fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy. RESULTS: We observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals. CONCLUSIONS: Feeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.
No takes yet. Share an insight, caveat, or question.
Mahaney et al. (2017) studied Early-stage atherosclerosis (n=112). High-cholesterol, high-fat challenge diet vs. Dietary control animals was evaluated on Evidence of atherosclerosis, circulating CVD risk biomarkers, and arterial compliance. Feeding a high-cholesterol, high-fat diet for two years induced atherosclerosis in 99.1% (111/112) of baboons and increased arterial stiffness vs controls.
Synapse has enriched 10 related papers. Consider them for comparative context: