What question did this study set out to answer?

To determine how age at type 1 diabetes diagnosis and traditional vascular risk factors influence the development of diabetic retinopathy over long-term follow-up.

January 1, 2016Journal of Diabetes ResearchOpen Access

Influence of Age at Diagnosis and Time-Dependent Risk Factors on the Development of Diabetic Retinopathy in Patients with Type 1 Diabetes

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Authors

LFLuis ForgaUniversidad de Navarra MGMaría José GoñiUniversidad Complutense de Madrid BIBerta IbáñezRed de Investigación en Actividades Preventivas y Promoción de la Salud

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Implication

Retrospective cohort study reveals increased diabetic retinopathy risk with older age at onset in type 1 diabetes, highlighting the impact of blood pressure and glycemic control.

Key Points

To determine how age at type 1 diabetes diagnosis and traditional vascular risk factors influence the development of diabetic retinopathy over long-term follow-up.
Observational, retrospective cohort study of 989 patients followed after diagnosis for a mean of 10.1 (SD: 6.8) years.
Assessed age at diagnosis, glycemic control, diabetes duration, sex, blood pressure, lipid profile, BMI, and smoking status using Cox univariate and multivariate models with fixed and time-dependent variables.
Diabetic retinopathy occurred in 135 patients (13.7%), with cumulative incidence rates of 0.7% at 5 years, 5.9% at 10 years, and 21.8% at 15 years.
Compared with diagnosis at age <10 years, retinopathy risk increased 2.5-fold for onset at 10–14 years, 3.0-fold at 15–29 years, 3.3-fold at 30–44 years, and 3.7-fold at >44 years.
Retinopathy development was significantly associated with HbA1c levels, HDL-cholesterol, and diastolic blood pressure during follow-up.

Cite This Study

Forga et al. (2016) studied this question.

synapsesocial.com/papers/6a7efdbc9dbaade951d0aa8a https://doi.org/10.1155/2016/9898309

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Implication

Retrospective cohort study reveals increased diabetic retinopathy risk with older age at onset in type 1 diabetes, highlighting the impact of blood pressure and glycemic control.

Influence of Age at Diagnosis and Time-Dependent Risk Factors on the Development of Diabetic Retinopathy in Patients with Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of Age at Diagnosis and Time-Dependent Risk Factors on the Development of Diabetic Retinopathy in Patients with Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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