Key result
Plasma insulin levels were negatively associated with intestinal MTP expression (β = -0.27, P=0.0005), whereas glucose levels were positively associated with MTP expression (β = 0.15, P=0.04).
Population
127 nondiabetic men free of intestinal disease displaying various degrees of insulin resistance. A subgroup…
Design
Cross-sectional
Authors
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May guide research on intestinal lipoprotein regulation in insulin resistance; leaves open clinical implications pending causal evidence.
Cross-Sectional (n=127)
Effect estimate: standard β = -0.27
p-value: p=0.0005
Plasma insulin and glucose levels are differentially associated with the expression of key genes involved in chylomicron metabolism, suggesting concurrent regulation of intestinal lipoprotein metabolism in insulin resistance.
Drouin‐Chartier et al. (2018) conducted a cross-sectional in Insulin resistance (n=127). Plasma insulin and glucose concentrations was evaluated on Intestinal expression of key genes involved in chylomicron metabolism (ACS1, DGAT1, DGAT2, MTP) (standard β = -0.27, p=0.0005). Plasma insulin levels were negatively associated with intestinal MTP expression (β = -0.27, P=0.0005), whereas glucose levels were positively associated with MTP expression (β = 0.15, P=0.04).
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