Bilateral ovarian abscesses following platelet-rich plasma injection for “ovarian rejuvenation”: a case report

Objective: To describe a case of severe infectious complications following ovarian platelet-rich plasma (PRP) injections for ovarian rejuvenation. Design: Case report. Subjects: A 45-year-old nulligravid woman with a history of uterine fibroids and ovarian cysts presenting to an academic medical center. Exposure: Ovarian PRP injections were performed at an outside facility. Following presentation, the patient was treated with intravenous antibiotics. Because of persistent symptoms and clinical deterioration, she subsequently underwent image-guided aspiration of bilateral tubo-ovarian abscesses. Main Outcome Measures: Resolution of infection and resumption of baseline activity and menstrual cycles. After treatment, she achieved full clinical recovery, resuming normal menses and activity within four months. Conclusion: Ovarian PRP injections, although increasingly marketed for "rejuvenation," carry risks of severe complications, including infection, such as tubo-ovarian abscess formation. This case underscores the need for caution and further investigation into the safety and efficacy of PRP for reproductive indications.