Why the study?
The study aimed to evaluate chronic kidney disease markers and their clinical and prognostic role in outpatients with heart failure using real-world registry data.
Population
19981 outpatients with heart failure in Russia
Comparison
Patients with chronic kidney disease and stratified by aGFR value
Design
Retrospective analysis of a prospective observational multicenter registry
Authors
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HF patients with reduced eGFR warrant intensified monitoring and GDMT; confirms kidney function as an independent prognostic marker.
Observational (n=19,981)
Yes
Hazard Ratio: 1.485 (95% CI 1.276–1.728)
Absolute Event Rate: 7.8% vs 4.4%
p-value: p=<0.001
Shlyakhto et al. (2025) conducted an observational in Heart failure (n=19,981). Decreased estimated glomerular filtration rate (aGFR <60 ml/min/1.73 m2) vs. aGFR ≥60 ml/min/1.73 m2 was evaluated on All-cause mortality (HR 1.485, 95% CI 1.276-1.728, p=<0.001). A decrease in estimated glomerular filtration rate (aGFR <60 ml/min/1.73 m2) in outpatients with heart failure was independently associated with a higher risk of all-cause death (HR 1.485).
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