Key result
The presence of nonsustained ventricular tachycardia was associated with a significantly higher 15-year all-cause mortality compared to patients without the arrhythmia (26.3% vs 15.9%, p = 0.021).
Why the study?
In hypertrophic cardiomyopathy, nonsustained ventricular tachycardia is associated with sudden death risk, but its incidence and clinical characteristics required assessment in a Brazilian cohort.
Does the presence of nonsustained ventricular tachycardia (NSVT) on 24-hour Holter monitoring predict higher 15-year all-cause mortality in patients with hypertrophic cardiomyopathy?
Cohort (n=763)
No
Does the presence of nonsustained ventricular tachycardia (NSVT) on 24-hour Holter monitoring predict higher 15-year all-cause mortality in patients with hypertrophic cardiomyopathy?
Absolute Event Rate: 26.3% vs 15.9%
p-value: p=0.021
In patients with hypertrophic cardiomyopathy, the presence of significant nonsustained ventricular tachycardia on 24-hour Holter monitoring is associated with significantly higher 15-year all-cause mortality.
Does not yet change Holter or ICD practice; leaves open SCD-specific risk and why incidence trailed prior series.
Background In hypertrophic cardiomyopathy (HCM), there is a well-known association between nonsustained ventricular tachycardia (NSVT) and the risk of sudden death. Objectives To assess the incidence of NSVT using 24-hour Holter monitoring in patients with HCM in a Brazilian cohort and correlate it with its characteristics and progression. Methods This retrospective study of patients with HCM used 24-hour Holter monitoring to assess the presence of long-lasting, fast NSVT (≥ 10 beats and heart rate ≥ 130 bpm) or the presence of at least 3 episodes of NSVT with ≥ 3 beats and heart rate ≥ 120 bpm. Continuous variables were shown as arithmetic means and standard deviations, and categorical variables were shown as absolute and relative frequencies. P < 0.05 was considered significant. Results We included 763 patients, 53.5% of whom were male. Their mean age was 52.6 years ± 16.7. NSVT was found in 10% (76 patients). Only 11 (1.4%) of them had NSVT with ≥ 10 beats and heart rate ≥ 130 bpm. There was no difference in the relationship between NSVT and sex, septum > 30 mm, age ≥ 40 years, betablocker dose, and presence of atrial fibrillation. In the group with NSVT, 15-year all-cause mortality was observed in 26.3%, compared to 15.9% in the group without NSVT (p = 0.021). Conclusions The presence of NSVT on 24-hour Holter monitoring occurred in 10% of patients. Long-lasting, fast NSVT was rare. The presence of NSVT was associated with higher overall mortality during follow-up.
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Arteaga-Fernández et al. (2025) conducted a cohort in Hypertrophic Cardiomyopathy (n=763). Nonsustained ventricular tachycardia (NSVT) vs. Absence of NSVT was evaluated on 15-year all-cause mortality (p=0.021). The presence of nonsustained ventricular tachycardia was associated with a significantly higher 15-year all-cause mortality compared to patients without the arrhythmia (26.3% vs 15.9%, p = 0.021).
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