Population
C2C12 myogenic cells (skeletal muscle myoblasts)
Design
Preclinical
Authors
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Acto-myosin inhibition uncouples myoblast proliferation from differentiation in vitro; leaves open whether Rho pathway targeting affects skeletal muscle regeneration in vivo.
In skeletal muscle myoblasts, the Rho pathway and regulation of acto-myosin contractility define a control point for conditional uncoupling of differentiation and the cell cycle.
Dhawan et al. (2004) studied this question.
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