Why the study?
Does multiplex PCR improve the detection of respiratory viruses compared to conventional techniques in children with acute respiratory illness?
Population
263 children admitted to hospital with an acute respiratory illness, and a broader cohort of children…
Comparison
Four multiplex PCR (m-PCR) assays vs Direct immunofluorescence assay and HuH7 cell…
Design
Cross-sectional
Authors
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May increase diagnostic yield in children with respiratory illness; leaves open effects on management and outcomes.
Does multiplex PCR improve the detection of respiratory viruses compared to conventional techniques in children with acute respiratory illness?
Multiplex PCR assays offer higher sensitivity, shorter diagnostic delay, and lower cost compared to conventional DFA and cell culture for detecting respiratory viruses in children.
Freymuth∘ et al. (2006) studied this question.
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