Key result
Metabolic syndrome was associated with significantly lower levels of mean strain, mean peak systolic strain rate, and mean peak early diastolic strain rate compared to healthy controls (P<0.05).
Why the study?
Metabolic syndrome predisposes to left ventricular dysfunction and heart failure, but alterations in left atrial function in metabolic syndrome remain unknown.
Does metabolic syndrome impair left atrial function as assessed by strain/strain rate imaging compared to healthy controls?
Case-Control (n=100)
No
Does metabolic syndrome impair left atrial function as assessed by strain/strain rate imaging compared to healthy controls?
Metabolic syndrome is associated with impaired left atrial function, which can be reliably detected and quantified using strain and strain rate echocardiographic imaging.
Strain imaging may detect subclinical LA dysfunction in metabolic syndrome; leaves open whether it improves risk stratification or outcomes.
Background: Metabolic syndrome (MS) predisposes to left ventricular dysfunction and heart failure, however, alterations in left atrial (LA) function in MS are unknown. Objectives: We aimed to use strain/strain rate (SR) imaging to investigate the effect of MS on LA function. Subjects and Methods: This prospective case control study included a total of 100 subjects divided in to 75 metabolic syndrome (MS) patients referred to Al-Azhar university hospital outpatient clinic for evaluation and treatment of hypertension and/or diabetes mellitus and 25 age and sex matched apparently healthy volunteers as a control group. All subjects underwent conventional echocardiographic examination and assessment of LA function by speckle tracking. Partial correlation and multiple stepwise regression analyses were used to determine the risk factors for impaired LA function. Results: Compared with the controls, the MS patients showed significantly lower levels of mean strain, mean peak systolic SR and mean peak early diastolic SR (P<0.05 for all), with no difference in the mean peak late diastolic SR. Central obesity, hypertension, dyslipidemia and uncontrolled diabetes were independent risk factors for impaired LA function. Conclusion: SR imaging is reliable in assessing LA function in MS patients.
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Allam et al. (2019) conducted a case-control in Metabolic syndrome (n=100). Metabolic syndrome vs. Healthy volunteers was evaluated on Left atrial function (mean strain, mean peak systolic SR, mean peak early diastolic SR) (p=<0.05). Metabolic syndrome was associated with significantly lower levels of mean strain, mean peak systolic strain rate, and mean peak early diastolic strain rate compared to healthy controls (P<0.05).
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