Key result
Metabolic syndrome in young adults linked to lower LA reservoir and conduit strain versus controls.
Why the study?
To evaluate 2D and 4D left atrial strain parameters and identify early markers of diastolic dysfunction in young adults with newly diagnosed metabolic syndrome.
Does left atrial strain assessment using 2D and 4D echocardiography identify early markers of diastolic dysfunction in young adults with newly diagnosed metabolic syndrome compared to healthy controls?
Observational
Does left atrial strain assessment using 2D and 4D echocardiography identify early markers of diastolic dysfunction in young adults with newly diagnosed metabolic syndrome compared to healthy controls?
Left atrial strain assessment using 2D speckle tracking echocardiography can identify early signs of diastolic dysfunction in young adults with newly diagnosed metabolic syndrome.
May flag early diastolic impairment in young metabolic syndrome patients; leaves open whether strain-guided management improves outcomes.
The aim of this article is to evaluate the parameters of left atrial (LA) strain in 2D and 4D modes and to identify early markers of diastolic dysfunction in young subjects (aged 18 to 44) with the first clinical and laboratory diagnosis of metabolic syndrome (MS) according to the criteria of the International Federation of Diabetologists (IDF). All subjects underwent transthoracic echocardiography (EchoCG) to study structural and functional changes in the myocardium, with an assessment of LA strain in 2D and 4D modes. In the work we determined markers of LV dysfunction using Speckle tracking technology, and also investigated correlations between the main components of MS and echocardiographic parameters. Using comparative analysis, the main group showed statistically lower values of LА strain during reservoir and conduit phases in 2D-mode compared to the control group. LА strain during the reservoir phase (LASr) in 2D combined with standard parameters of left ventricular diastolic function such as LASr/(VE/e’mean), VE/LASr also had significant differences in subjects with MS. Components of MS such as obesity (body mass index, waist circumference), arterial hypertension (elevated systolic blood pressure), dyslipidemia (hypertriglyceridemia) and glycemia had moderate negative correlations with LASr in 2D when identifying a group of patients with LA strain during the reservoir phase of less than 43.5%, based on the lower quartile of healthy individuals.
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Bartosh‐Zelenaya et al. (2025) conducted an observational in Metabolic syndrome. Metabolic syndrome vs. Healthy individuals (control group) was evaluated on Left atrial strain during reservoir and conduit phases in 2D and 4D modes. Young adults with metabolic syndrome had significantly lower left atrial strain during reservoir and conduit phases compared to healthy controls, with MS components correlating with LASr <43.5%.
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