Key result
Eleven plasma metabolites, including lipids in the dihydrosphingomyelin and sphingosine pathways, were independently associated with orthostatic systolic blood pressure responses after adjustment for cardio-metabolic disease markers.
Why the study?
Although autonomic dysfunction and metabolic syndrome are clinically linked, their relationships with the plasma metabolome remain unknown.
Cross-Sectional (n=3,803)
No
Effect estimate: β -0.70 (95% CI -1.26 to -0.37)
p-value: p=3.42 × 10^-5
Specific plasma metabolites, particularly sphingolipids, are independently associated with orthostatic blood pressure responses, suggesting a metabolic link to cardiovascular autonomic dysfunction.
Metabolite associations with orthostatic BP responses are hypothesis-generating; leaves open causal or prognostic roles pending longitudinal validation.
Whereas autonomic dysfunction and the metabolic syndrome are clinically associated, the relationships with the plasma metabolome is unknown. We explored the association between orthostatic blood pressure responses and 818 plasma metabolites in middle-aged subjects from the general population. We included 3803 out of 6251 subjects (mean age, 57 years; 52% women) from the Malmö sub-cohort of The Swedish CardioPulmonary bioImage Study with information on smoking habits, diabetes, antihypertensive drug treatment, anthropometrics, hemodynamic measurements and 818 plasma metabolites (mass-spectrometry). The associations between each metabolite and orthostatic systolic blood pressure responses were determined using multivariable linear regression analysis and p values were corrected using the Bonferroni method. Six amino acids, five vitamins, co-factors and carbohydrates, nine lipids and two xenobiotics were associated with orthostatic blood pressure after adjusting for age, gender and systolic blood pressure. After additional adjustments for BMI, diabetes, smoking and antihypertensive treatment, the association remained significant for six lipids, four amino acids and one xenobiotic. Twenty-two out of 818 plasma metabolites were associated with orthostatic blood pressure responses. Eleven metabolites, including lipids in the dihydrosphingomyelin and sphingosine pathways, were independently associated with orthostatic systolic blood pressure responses after additional adjustment for markers of cardio-metabolic disease.
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Zambach et al. (2023) conducted a cross-sectional in Orthostatic blood pressure responses (n=3,803). Plasma metabolites was evaluated on Orthostatic systolic blood pressure response (association with Behenoyl Dihydrosphingomyelin) (β -0.70, 95% CI -1.26 to -0.37, p=3.42 × 10^-5). Eleven plasma metabolites, including lipids in the dihydrosphingomyelin and sphingosine pathways, were independently associated with orthostatic systolic blood pressure responses after adjustment for cardio-metabolic disease markers.
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