Key result
In older nondiabetic adults, a one-SD increment in plasma fibrinogen was independently associated with orthostatic hypotension (adjusted OR 1.45; 95% CI 1.06-1.99; P=0.02).
Why the study?
Is orthostatic blood pressure response associated with carotid intima-media thickness and plasma fibrinogen in older nondiabetic adults?
Population
700 nondiabetic adults, age 64 years, 43% men
Comparison
Orthostatic hypotension and orthostatic… vs Normal orthostatic blood pressure response
Design
Cross-sectional
Authors
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Fibrinogen may mark orthostatic hypotension risk in older nondiabetics; leaves open causal role and need for longitudinal outcome studies.
Cross-Sectional (n=700)
Is orthostatic blood pressure response associated with carotid intima-media thickness and plasma fibrinogen in older nondiabetic adults?
Odds Ratio: 1.45 (95% CI 1.06–1.99)
p-value: p=0.02
In older nondiabetic adults, orthostatic hypotension, but not orthostatic hypertension, correlates with systemic inflammation and potentially increased carotid atherosclerosis.
Fedorowski et al. (2012) conducted a cross-sectional in Nondiabetic adults (n=700). Plasma fibrinogen (per one-SD increment) vs. Lower levels was evaluated on Orthostatic hypotension (OR 1.45, 95% CI 1.06-1.99, p=0.02). In older nondiabetic adults, a one-SD increment in plasma fibrinogen was independently associated with orthostatic hypotension (adjusted OR 1.45; 95% CI 1.06-1.99; P=0.02).
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