Key result
Individual and combined treatments with nebivolol, lisinopril, and valsartan reduced mean blood pressure and decreased vascular reactivity to angiotensin II and norepinephrine in hypertensive rats.
Why the study?
Because some antihypertensive combinations have been shown to be ineffective, it is necessary to determine differences between monotherapy and combination therapy by temporally monitoring vascular responses to angiotensin II and norepinephrine.
Do individual and combined treatments with nebivolol, lisinopril, and valsartan reduce blood pressure and vascular reactivity in spontaneously hypertensive rats?
Do individual and combined treatments with nebivolol, lisinopril, and valsartan reduce blood pressure and vascular reactivity in spontaneously hypertensive rats?
In a rat model of hypertension, monotherapy and combination therapy with nebivolol, lisinopril, and valsartan effectively reduced blood pressure and vascular reactivity to vasoconstrictors.
I need the paper’s actual verdict and methods before I can write a complementary implication. Searching now.Found the paper. Pulling the full text and results next.PDF and PubMed pages next — I need the actual results, not just the title.Should not yet change practice; leaves open whether time-dependent vascular reactivity differences between nebivolol combinations apply in humans.
Clinical guidelines suggest the combination of 2 drugs as a strategy to treat hypertension. However, some antihypertensive combinations have been shown to be ineffective. Therefore, it is necessary to determine whether differences exist between the results of monotherapy and combination therapy by temporal monitoring of the responses to angiotensin II and norepinephrine, which are vasoconstrictors involved in the development of hypertension. Thus, the purpose of this work was to determine the vascular reactivity to angiotensin II and norepinephrine in spontaneously hypertensive rat (SHR) aortic rings after treatment with valsartan, lisinopril, nebivolol, nebivolol-lisinopril, and nebivolol-valsartan for different periods of time. In this study, male SHR and Wistar Kyoto normotensive (WKY) rats were divided into 7 groups treated for 1, 2, and 4 weeks: (1) WKY + vehicle, (2) SHR + vehicle; (3) SHR + nebivolol; (4) SHR + lisinopril; (5) SHR + valsartan; (6) SHR + nebivolol-lisinopril; and (7) SHR + nebivolol-valsartan. Blood pressure was measured by the tail-cuff method, and vascular reactivity was determined from the concentration-response curve to angiotensin II and norepinephrine in aortic rings. The results showed that the combined and individual treatments reduced mean blood pressure at all times evaluated. All treatments decreased vascular reactivity to angiotensin II; however, in the case of lisinopril and nebivolol-lisinopril, the effect observed was significant up to 2 weeks. All treatments decreased the reactivity to norepinephrine up to week 4. These results show a time-dependent difference in vascular reactivity between the pharmacological treatments, with nebivolol-valsartan and nebivolol-lisinopril being both effective combinations. Additionally, the results suggest crosstalk between the renin-angiotensin and sympathetic nervous systems to reduce blood pressure and to improve treatment efficacy.
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Lezama‐Martínez et al. (2021) studied hypertension. valsartan, lisinopril, nebivolol, nebivolol-lisinopril, and nebivolol-valsartan vs. vehicle was evaluated on mean blood pressure and vascular reactivity to angiotensin II and norepinephrine. Individual and combined treatments with nebivolol, lisinopril, and valsartan reduced mean blood pressure and decreased vascular reactivity to angiotensin II and norepinephrine in hypertensive rats.
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