October 1, 1995Annals of Internal Medicine
Diuretics, β-Blockers, and the Risk for Sudden Cardiac Death in Hypertensive Patients
Why the study?
Does the use of non-potassium-sparing diuretics and beta-blockers increase the risk of sudden cardiac death in hypertensive patients?
Population
514 hypertensive patients receiving drug therapy for hypertension in Rotterdam, the Netherlands.
Comparison
Non-potassium-sparing diuretics and/or… vs Reference group treated primarily with…
Design
Case-control
Authors
Discussion
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Member takes
Implication
Supports preferring potassium-sparing diuretics in hypertension but should not change practice; leaves open randomized confirmation of sudden death benefit.
Structured PICO
Does the use of non-potassium-sparing diuretics and beta-blockers increase the risk of sudden cardiac death in hypertensive patients?
P
Population
514 hypertensive patients (257 case-patients who died suddenly and 257 living controls) receiving drug therapy for hypertension in Rotterdam, the Netherlands.
I
Intervention
Non-potassium-sparing diuretics and/or beta-blockers
C
Comparator
Reference group treated primarily with potassium-sparing diuretics
O
Outcome
Sudden cardiac deathhard clinical
The use of non-potassium-sparing diuretics and beta-blockers in hypertensive patients is associated with an increased risk of sudden cardiac death compared to potassium-sparing diuretics.
Cite This Study
Arno W. Hoes (1995) studied this question.