Why the study?
Does acute, progressive isocapnic hypoxia elicit a different heart rate response in patients with COPD compared to normal controls?
Population
55 subjects: 31 patients with chronic obstructive pulmonary disease (COPD) and 24 normal control subjects
Comparison
Acute, progressive isocapnic hypoxia vs Normal control subjects
Design
Case-control
Authors
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Augmented hypoxic heart rate response may indicate autonomic changes in COPD; leaves open prognostic or therapeutic implications.
Does acute, progressive isocapnic hypoxia elicit a different heart rate response in patients with COPD compared to normal controls?
Patients with COPD exhibit an augmented heart rate response to acute hypoxia compared to normal controls, which correlates with the severity of airway obstruction.
Miyamoto et al. (1992) studied this question.
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