Key result
Endothelial microparticle levels were significantly higher in patients with coronary intermediate lesions compared to normal subjects, but showed no correlation with fractional flow reserve.
Why the study?
Is endothelial microparticle (EMP) level associated with fractional flow reserve (FFR) in patients with coronary intermediate lesions?
Observational (n=73)
Is endothelial microparticle (EMP) level associated with fractional flow reserve (FFR) in patients with coronary intermediate lesions?
Circulating EMP is elevated in patients with coronary intermediate lesions but does not correlate with FFR, suggesting it is a systemic rather than focal marker of endothelial dysfunction.
Does not support EMP as a surrogate for FFR in intermediate lesions; leaves open its role as a systemic endothelial marker.
Endothelial microparticle (EMP) is a biomarker for endothelial dysfunction. The aim of this study is to investigate the utility of EMP in evaluating coronary intermediate lesions. Participants included 49 patients with coronary intermediate lesions and 24 subjects with normal coronary arteries. Among these subjects, 28 patients accepted fractional flow reserve (FFR). Results showed that level of EMP was significantly higher in the intermediate lesion group. No correlation was found between EMP and FFR value, suggesting that circulating EMP is a systemic marker rather than a focal one.
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Song et al. (2015) conducted an observational in Coronary intermediate lesions (n=73). Endothelial microparticle (EMP) levels vs. Subjects with normal coronary arteries was evaluated on EMP levels and correlation with fractional flow reserve (FFR). Endothelial microparticle levels were significantly higher in patients with coronary intermediate lesions compared to normal subjects, but showed no correlation with fractional flow reserve.
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