Key result
Oral administration of licorice root ethanol extract significantly decreased serum AST and ALT activity in alloxan-induced diabetic rats (p<0.001) but had no significant effect in normal rats.
Why the study?
Does ethanol extract of licorice root reduce liver enzyme activity in alloxan-induced diabetic rats?
Does ethanol extract of licorice root reduce liver enzyme activity in alloxan-induced diabetic rats?
p-value: p=<0.001
Licorice root extract demonstrates hepatoprotective effects by reducing elevated liver enzymes in a rat model of alloxan-induced diabetes.
Hypothesis-generating for hepatoprotection in diabetic models; human trials needed before clinical consideration.
Background: Licorice (Glycyrrhiza glabra L., Fabaceae) is a well-known herb that it used in traditional medicine due to pharmacological activities. Licorice in herbal medicine is used as a tonic, expectorant and demulcent factor. This plant has antioxidant, immunostimulant, anti-allergenic and anti-ulcer activities. The aim of present study was to, comparisons of effect of ethanol extracts licorice root with glibenclamide on activity of liver enzymes in normal and alloxan-induced diabetic rats.
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Eidi et al. (2016) studied Alloxan-induced diabetes (n=60). Ethanol extract of licorice root (Glycyrrhiza glabra L.) vs. Untreated diabetic control and glibenclamide was evaluated on Serum ALT and AST activity (p=<0.001). Oral administration of licorice root ethanol extract significantly decreased serum AST and ALT activity in alloxan-induced diabetic rats (p<0.001) but had no significant effect in normal rats.
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