Key result
Thoracic epidural anesthesia with or without general anesthesia did not significantly reduce the risk of mortality (RR 0.89) or myocardial infarction compared to general anesthesia alone in patients undergoing cardiac surgery.
Why the study?
Does thoracic epidural anesthesia with or without general anesthesia reduce mortality, myocardial infarction, and perioperative complications in adult patients undergoing cardiac surgery?
Population
25 RCTs pooling 3,062 adult patients (≥18 years) undergoing cardiac surgery.
Comparison
Thoracic epidural anesthesia with or without… vs General anesthesia (GA) alone
Design
Meta-analysis
Follow-up
short-term and long-term after operation
Authors
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Adds no mortality or MI benefit in cardiac surgery; confirms general anesthesia alone for these primary endpoints.
Meta-Analysis (n=3,062)
Does thoracic epidural anesthesia with or without general anesthesia reduce mortality, myocardial infarction, and perioperative complications in adult patients undergoing cardiac surgery?
Relative Risk: 0.89 (95% CI 0.42–1.87)
p-value: p=>0.05
Thoracic epidural anesthesia during cardiac surgery does not significantly reduce mortality or myocardial infarction but significantly decreases respiratory complications, supraventricular arrhythmias, and ICU length of stay.
Zhang et al. (2015) conducted a meta-analysis in Cardiac surgery (n=3,062). Thoracic epidural anesthesia (TEA) vs. General anesthesia (GA) alone was evaluated on Mortality (RR 0.89, 95% CI 0.42, 1.87, p=>0.05). Thoracic epidural anesthesia with or without general anesthesia did not significantly reduce the risk of mortality (RR 0.89) or myocardial infarction compared to general anesthesia alone in patients undergoing cardiac surgery.
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