Why the study?
Does hyperinsulinemia increase risk factors for coronary artery disease in healthy, normotensive, nonobese subjects with normal glucose tolerance?
Population
64 healthy, normotensive nonobese subjects with normal glucose tolerance, drawn from a larger cohort of 247…
Comparison
Hyperinsulinemia vs Normoinsulinemia, matched for age, sex, and…
Design
Case-control
Authors
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May mark higher CAD risk in healthy adults; leaves open causality and need for prospective trials.
Does hyperinsulinemia increase risk factors for coronary artery disease in healthy, normotensive, nonobese subjects with normal glucose tolerance?
Healthy, normotensive, nonobese individuals with hyperinsulinemia and normal glucose tolerance exhibit an adverse cardiovascular risk profile, including dyslipidemia and elevated blood pressure.
Zavaroni et al. (1989) studied this question.
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