What question did this study set out to answer?

Review the immunological roles of key micronutrients—including vitamin A, vitamin D, iron, zinc, and selenium—and synthesize evidence on how micronutrient deficiencies interact with infectious pathogens to affect child health.

May 9, 2024Annual Review of NutritionOpen Access

Interactions of Nutrition and Infection: The Role of Micronutrient Deficiencies in the Immune Response to Pathogens and Implications for Child Health

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Authors

APAmanda PalmerJohns Hopkins University JBJacquelyn BedsaulNational Cancer Institute CSCharles B. StephensenWestern Human Nutrition Research Center

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Implication

Review demonstrates complex interactions between micronutrient deficiencies and pathogen defense in pediatric populations, highlighting critical nutrition targets to reduce child mortality.

Key Points

Review the immunological roles of key micronutrients—including vitamin A, vitamin D, iron, zinc, and selenium—and synthesize evidence on how micronutrient deficiencies interact with infectious pathogens to affect child health.
Narrative synthesis of evidence evaluating cellular and molecular immune mechanisms regulated by vitamin A, vitamin D, iron, zinc, and selenium.
Analysis of synergistic and antagonistic interactions between micronutrient deficiencies and major pediatric pathogens (including agents of diarrhea, malaria, and respiratory infections) in low- and middle-income countries.
Pathogen-induced inflammatory responses exacerbate micronutrient depletion by inducing anorexia, impairing intestinal absorption, and driving nutrient losses.
Deficiencies in key micronutrients compromise cellular host defenses, weaken protection against oxidative stress and inflammation, and significantly elevate child morbidity and mortality.

Cite This Study

Palmer et al. (2024) studied this question.

synapsesocial.com/papers/6a7f0b5dc8c4b7909d69a387 https://doi.org/10.1146/annurev-nutr-062122-014910

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Implication

Review demonstrates complex interactions between micronutrient deficiencies and pathogen defense in pediatric populations, highlighting critical nutrition targets to reduce child mortality.

Interactions of Nutrition and Infection: The Role of Micronutrient Deficiencies in the Immune Response to Pathogens and Implications for Child Health

Discussion

Member takes

Implication

Key Points

Cite This Study

Interactions of Nutrition and Infection: The Role of Micronutrient Deficiencies in the Immune Response to Pathogens and Implications for Child Health

Discussion

Member takes

Implication

Key Points

Cite This Study

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